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Francisco Morís Selected Research

demycarosyl-3D-digitoxosylmithramycin SK

9/2020Mithramycin A and Mithralog EC-8042 Inhibit SETDB1 Expression and Its Oncogenic Activity in Malignant Melanoma.
8/2019The SRC Inhibitor Dasatinib Induces Stem Cell-Like Properties in Head and Neck Cancer Cells that are Effectively Counteracted by the Mithralog EC-8042.
5/2016Inhibition of SP1 by the mithramycin analog EC-8042 efficiently targets tumor initiating cells in sarcoma.
10/2015Antitumoral activity of the mithralog EC-8042 in triple negative breast cancer linked to cell cycle arrest in G2.
10/2015Cytotoxic effects of mithramycin DIG-MSK can depend on the rise of autophagy.
1/2015Pleiotropic Anti-Angiogenic and Anti-Oncogenic Activities of the Novel Mithralog Demycarosyl-3D-ß-D-Digitoxosyl-Mithramycin SK (EC-8042).
8/2014The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription.
1/2014Genome-wide modulation of gene transcription in ovarian carcinoma cells by a new mithramycin analogue.
11/2012Novel mithramycins abrogate the involvement of protein factors in the transcription of cell cycle control genes.

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Francisco Morís Research Topics

Disease

13Neoplasms (Cancer)
04/2023 - 01/2012
5Carcinoma (Carcinomatosis)
01/2021 - 11/2012
3Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
03/2022 - 01/2018
2Sarcoma (Soft Tissue Sarcoma)
03/2021 - 05/2016
2Melanoma (Melanoma, Malignant)
09/2020 - 06/2012
2Squamous Cell Carcinoma of Head and Neck
08/2019 - 09/2018
2Prostatic Neoplasms (Prostate Cancer)
01/2016 - 01/2012
2Triple Negative Breast Neoplasms
10/2015 - 09/2015
2Carcinogenesis
10/2015 - 01/2015
2Ovarian Neoplasms (Ovarian Cancer)
08/2014 - 01/2014
1Renal Cell Carcinoma (Grawitz Tumor)
04/2023
1Myxoid Liposarcoma
03/2021
1Chondrosarcoma
03/2021
1Colonic Neoplasms (Colon Cancer)
01/2021
1Adenocarcinoma of Lung
01/2021
1Leukemia
01/2021
1Head and Neck Neoplasms (Head and Neck Cancer)
08/2019
1Hypercalcemia (Milk Alkali Syndrome)
01/2018
1Ewing Sarcoma (Sarcoma, Ewing)
08/2016
1Tics (Tic)
05/2016
1Disease Progression
01/2016
1Colorectal Neoplasms (Colorectal Cancer)
10/2015

Drug/Important Bio-Agent (IBA)

9demycarosyl-3D-digitoxosylmithramycin SKIBA
09/2020 - 11/2012
8PlicamycinFDA Link
03/2021 - 01/2012
5mithramycin AIBA
04/2023 - 11/2012
3Phosphotransferases (Kinase)IBA
03/2022 - 09/2015
3Transcription Factors (Transcription Factor)IBA
08/2016 - 01/2012
2Anti-Bacterial Agents (Antibiotics)IBA
03/2021 - 11/2012
2Protein Kinases (Protein Kinase)IBA
10/2015 - 09/2015
2mithramycin SKIBA
10/2015 - 11/2012
1Sirolimus (Rapamycin)FDA Link
04/2023
18- (6- methoxypyridin- 3- yl)- 3- methyl- 1- (4- piperazin- 1- yl- 3- trifluoromethylphenyl)- 1,3- dihydroimidazo(4,5- c)quinolin- 2- oneIBA
04/2023
1Immunoconjugates (Immunoconjugate)IBA
04/2023
1Microphthalmia-Associated Transcription FactorIBA
04/2023
1glembatumumab vedotinIBA
04/2023
1MicellesIBA
03/2021
1Nanoparticle Drug Delivery SystemIBA
03/2021
1NaphthalimidesIBA
01/2021
1EnzymesIBA
09/2020
1Mitogen-Activated Protein KinasesIBA
09/2020
1Histone MethyltransferasesIBA
09/2020
1Dasatinib (BMS 354825)FDA Link
08/2019
1saracatinibIBA
08/2019
1src-Family KinasesIBA
08/2019
1Conditioned Culture MediaIBA
09/2018
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
01/2018
1proto-oncogene proteins pimIBA
01/2018
1EWS-FLI fusion proteinIBA
08/2016
1Doxorubicin (Adriamycin)FDA LinkGeneric
05/2016
1ErbB Receptors (EGF Receptor)IBA
10/2015
1Messenger RNA (mRNA)IBA
01/2015
1LuciferasesIBA
08/2014
1Pemetrexed (MTA)FDA Link
08/2014
1DNA (Deoxyribonucleic Acid)IBA
01/2014
1Antineoplastic Agents (Antineoplastics)IBA
06/2012
1Proteins (Proteins, Gene)FDA Link
01/2012
1Sp Transcription FactorsIBA
01/2012

Therapy/Procedure

4Therapeutics
04/2023 - 01/2012
1Oral Administration
01/2018
1Drug Therapy (Chemotherapy)
09/2015